A recent study has unveiled the connection of persistent overeating and stress with increased risk of developing depression and anxiety. A group of researcher from Yale University vigorously studied this issue and noted that the anesthetic ketamine reverse depression like symptoms in rats are similar with people. Rats those were provided a high fat diet developed and battled chronic depression and synaptic damage of chronic stress the exact same way people do.
Ronald Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry, professor of neurobiology, and senior author of the research paper commented “The effects of a high-fat diet overlap with those of chronic stress and could also be a contributing factor in depression as well as metabolic disorders such as Type 2 diabetes,” .The research team published the paper in the journal Neuropharmacology.
According to the study team of Yale, ketamine or the famous “Special K” which is abused by many as a recreational drug have ability to dramatically subdue the major symptoms of chronic depression in patients who are even impenetrable with regular antidepressant agents. Additional research on this drug also proved that ketamine activates the mTORC pathway, which modulates the synthesis of proteins involved in creation of synaptic connections in the brain that are damaged by stress and depression.
The research team further stated that this pathway is involved in cellular responses to energy and metabolism, and people with metabolic disorders like Type 2 diabetes are at a position of higher and greater risk of growing depression. The team ran an investigation in the lab on rats , fed them a diet that have six times the normal amount of fat compare to regular diets of rats. After four months passed in this diet, pathways involved with both synaptic plasticity and metabolism were disrupted. Following this, the rats exhibited a sign of deep depression and anxiety. In their study , the team stated that a single low dose of ketamine reversed those symptoms quickly, and reversed the disruption of mTORC signaling pathways.
Ronald Duman, the chief research also stated that the effects of ketamine on metabolism need more through research to understand and its proper dosage and use for depression are still a subject of clinical trials.